ACTIVIN A TARGETS EXTRASYNAPTIC NMDA RECEPTORS TO AMELIORATE NEURONAL AND BEHAVIORAL DEFICITS IN A MOUSE MODEL OF HUNTINGTON DISEASE

Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease

Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD).A previous study showed Activin A, whose transcription is upregulated by calcium influx via synaptic NMDARs, suppresses eNMDAR signaling.Therefore, we examined th

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A Theory on Local Governance of Organizations in Iran

In countries with different ethnics, local people highly seeking to control local internal affairs administration by themselves.If central power Stainless cannot, in stable conditions, guide this tendency well, and reinforce national consensus field, in instable conditions, disintegration field of the country will be provided.In historical backgrou

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